In a blue-collar town in Pennsylvania, a 32-year-old woman's teen daughter goes missing and she is left to raise her infant grandson alone. The story is told over the course of 11 years: we journey with her from the time her daughter vanishes, through the trials-and-tribulations of subsequent years, and ultimately to the long-awaited discovery of the truth.

The story follows Dever and Feldstein's characters, two academic superstars and best friends who, on the eve of their high school graduation, suddenly realize that they should have worked less and played more. Determined never to fall short of their peers, the girls set out on a mission to cram four years of fun into one night.